christian louboutin sale Some issues related to Al

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Some issues related to Alzheimer's disease

Changes in AD and other factors may play a key role in the pathogenesis. Now considered. The clinical changes in AD cerebral cortex and the edge of the main and the degenerative diseases of the nervous system related. Such as the hippocampus and neocortex of diffuse neuronal loss, intracellular neurofibrillary tangles and extracellular deposition of amyloid plaques and degeneration of peripheral neurons. Three caught with amyloid B (AB) the accumulation of relevant, so the latter is considered an important part of AD pathology. A13 is the amyloid precursor protein (APP) by proteolytic enzymes after the product of its participation in the formation of senile plaques. A13 There are two forms,[link widoczny dla zalogowanych], one is A1340, healthy elderly and AD patients exist in the body; the other is the A1342, mainly in the brain of AD patients. A1342 aggregation and neurotoxicity than A1340 from strong and can promote the formation of senile plaques increase. CAA is amyloid in leptomeningeal and cortical blood vessels due to deposition. Reported in 1975. In the autopsy of the brain of AD patients 87% have CAA. In 1984,[link widoczny dla zalogowanych], an AD-related CAA and the A13 is confirmed. A13 protein from 39 to 42 amino acids constitute the peptide chain. SP senile plaques in the long arm of the main A13 protein is 42-43 base pairs, and cerebral vascular A13 protein are mainly 39,40 on the base. A13 protein deposition in the brain in real terms in the formation of SP or neuritic plaques. Deposited in the vessel wall have resulted in CAA. CAA AD has been considered the most common vascular pathology. 80% ~ l00% AD patients with cerebral amyloid deposition of the wall. More common in the small arteries. CAA and recognized hereditary late-onset AD risk factor for an apolipoprotein (EE4) allele (ApoEE4) closely related; but with early-onset AD-related presenilin gene (Ps-1) and the Notch signaling pathway relationship has not been confirmed. And the pathological changes of AD such as the traditional SP,[link widoczny dla zalogowanych], NF'1 'and other cerebral vascular disease also correlated unclear. Lobar hemorrhage in CAA is the main reason for the elderly: the same time is also very common in AD and severe CAA was significantly associated with AD. CAA in the pia mater, the cerebral cortex and cerebellum of blood vessels in real terms, the most common and occipital lobe involvement the most. 3 prevention. Strengthen the mission; attention to MCI. There is no doubt a positive early intervention and other dementia are AD pathological brain aging, dementia is a group of highly disabling disease with high mortality. To donepezil (donepezi!) and rivastigmine (ri.vastigmine) the advent of a new generation of cholinesterase inhibitors (including of course China's pharmaceutical research and development of Huperzine workers) is an important drug treatment of dementia progress. Evidence-based medicine studies show that they really can slow down the process of dementia, some cognitive function improved. New antipsychotics and antidepressants in adverse reactions and characterized by light,[link widoczny dla zalogowanych], you can safely and effectively control the excitement of depression and anxiety in patients with dementia and other mental and behavioral symptoms of impulsivity, the lifting of these secondary symptoms that improve the quality of life of patients, reduce the burden on caregivers, but also life skills training, cognitive rehabilitation psychosocial interventions may be implemented. There cerebral circulation improving agent, and calcium antagonists: cyclandelate, nimodipine equality; promote brain cell metabolism drugs: adjoin polyvinylpyrrolidone type, such as citicoline; free radical scavengers: Ginkgo biloba extract neuroprotective agents, etc. and so can only alleviate some symptoms of dementia is relatively slow process, so the prevention of dementia and early intervention is of great importance. Mild cognitive impairment (mildeongnitiveimparment, MCI), an occurrence of the syndrome in the elderly population, the heterogeneity of brain aging is an important stage in the incidence of dementia is often an early warning signal! Seize this window of treatment time, prevention or delay the success rate of dementia will be greatly improved. MCI was established in 1997 Perterson diagnostic criteria: (1) complained of memory impairment and insider confirmed; (2) normal general cognitive function but may have some cognitive aspects of change; 3) normal activities of daily living; (4 ) with the same age and educational level were more there is memory impairment, memory function score in the match group score of 1.5 standard deviations below; (5) inadequate diagnostic criteria for dementia. Of course,[link widoczny dla zalogowanych], the prevention of dementia Children from the beginning of a healthy lifestyle. Raise the level of education (incidence rate of dementia and is inversely proportional to the level of education); control of blood glucose and lipid blood pressure; quit alcohol limit; lower level with cystine; attention to mental health, to avoid the depressive episode, to avoid excessive stress in life. Mission should increase efforts to spread missionary plane. Received Date: 2O07 an Ol-l8
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