timberland scarpe Children common lymphoid hematop

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Children common lymphoid hematopoietic tumor diagnosis and differential diagnosis

Eosinophilic granules (Giemsa staining in azure tropic particles); in the HE sections, carefully looking for with eosinophilic granular cytoplasm of immature neutrophils (original myeloid, promyelocytic cells and the promyelocytic), especially in the edge of the tumor and blood vessels nearby. The results of immunohistochemical staining MPO +, CD43 +, CD3 one, CD20 one. 4. Differential diagnosis: (1) acute myeloid leukemia (AML): AML extramedullary infiltration in morphological differences with the EMT is not to rely on clinical bone marrow,[link widoczny dla zalogowanych], peripheral blood examination to differentiate. In determining the source of the tumor granulocytes, should check the blood and bone marrow to rule out acute myeloid leukemia. (2) L and large cell lymphoma: identification can sometimes cause problems, particularly the lack of leukemia in patients with history. Granulocytic sarcoma is extremely similar in morphology, lymphoma,[link widoczny dla zalogowanych], particularly L. Granulocytic sarcoma with CD43-positive,[link widoczny dla zalogowanych], more easily misdiagnosed as T-cell L. Particles in the cytoplasm of tumor cells in Giemsa stained imprint the most easy to identify. In the paraffin section diagnosis of granulocytic sarcoma can be confirmed by chlorine acetate esterase staining. CD15 and CD68 as a monocyte and granulocyte cell markers can help diagnose. Myeloperoxidase is the most sensitive and specific work in paraffin sections myeloid differentiation marker. Occasionally individual medullary tumor extranodal positive for TdT, when MPO or neutrophil elastase-positive diagnostic value. Will be misdiagnosed as lymphoma EMT consequences are serious, because myeloid sarcoma (acute myeloid leukemia) and lymphomas of different chemotherapy regimens, misdiagnosis may miss the best time for treatment in children. The correct diagnosis depends on the pathologists see the (3) chronic myeloid leukemia (CML): CML can also be infiltrated lymph nodes, at this time is not only immature granulocyte infiltration, but by myeloid cells at all stages of the system. With a lack of red blood cells and megakaryocyte system components. Patients with chronic myeloid leukemia extramedullary blast crisis sometimes (acute myelogenous leukemia), MPO staining may be negative at this time, how to prove it? CD43,[link widoczny dla zalogowanych], CD34, CD117 positive, both B cells and T cell markers negative. Chronic myeloid leukemia acute lymphoblastic changes can also occur at this time TdT positive. (4) occurs when bone marrow hyperplasia in the lymph node extramedullary hematopoiesis (extramedullaryhemopoiesis), may sometimes be misdiagnosed as granulocytic sarcoma,[link widoczny dla zalogowanych], extramedullary hematopoiesis should be seen but the granulocyte, erythrocyte and megakaryocyte system in at least two systems of cells, but also the differentiation from immature to mature series exist. Not sure, you can use red blood cell marker glycophorin (glycophorinA) and megakaryocytic markers of platelet glycoprotein (plateletglycoprotein) confirmed.
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