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Treated Xiaoguishao 119 examples of candidate precancerous lesions Efficacy

Chinese papers League finishing. Abstract To observe particles Xiaoguishao treatment of gastric precancerous lesions (PLGC) clinical efficacy. Methods 236 patients were randomly divided into 2 groups PLGC. 119 cases to the treatment group Xiaoguishao particles, each one bag, taking 30min before meals 3 times a day; the control group 117 patients to Weifuchun tablets, 4 tablets each time, before meals, taking 30min, 3 times a day. Group 2 course of treatment was 3 months, observed syndromes. Results The total effective rate was 90.76%, 71.79% in control group, 2 groups was statistically significant difference (P 0.05); the two treatment groups on the stomach and threatened fullness, stomach pain significantly better than the control group (P 0.05); treatment group on red tongue, dark red tongue with petechiae, greasy fur, and fur Huang significantly better than the control group (P 0.05). Conclusion particles Xiaoguishao curative treatment of gastric precancerous lesions. Key words precancerous condition; blood; spleen; heat; stomach cancer Clinical effect of granula of Xiaoguishao granula of traditional Chinese herbs on patients with precancerous lesions of gastric cancer WANG Zhikun, LIUHong, ZHANGWEi Dept.of Digestion, HebEI Provincial Hospital of Traditional Chi-nese Medicine, Shijiazhuang, 050011 【Abstracts】 Objective To observe to clinical effect of granula of Xiaoguishao granula of traditional Chinese herbs on patients with precancerous lesions of gastric cancer.Methods 236patients with precancerous lesions of gastric cancer were randomly divided into two groups.119patients in the treatment group were administrated Xiaoguishao granula according to different symptoms and signs3times a day, one pouch each time, 30min before meal.117patients in the control group were given the tables of Wei fu-chun, 3times a day, 4tables each times, 30min before meal, for three months . Results The total effective rate in treatment group was90.76% and that in the control was71.79%. There was a significant dif-ference in manifestation curative effect between two groups (P 0.05) between two groups.The curative effects of treatment group is higher than that in the control group to treat hypochondrial distending pain and stomachache (P 0.05). There were significant difference between two groups in curative effect of red tongue, dark-red tongue companying stagnant blood, white-greasy coating tongue and in yellow coating tongue (P 0.05). Conclusion There is a definite effect of granula of Xiaoguishao of traditional Chinese herbs on pa-tients with precancerous lesions of gastric cancer. 【Key Words】 Granula of Xiaoguishao of traditional Chinese herbs; Precancerous lesions of gastric cancer; Promoting blood flow; Invigorate the spleen precancerous lesions (precancerous lesions of gastric cancer, PL-GC) is defined on the basis of atrophic gastritis associated with severe intestinal metaplasia and dysplasia, and gastric cancer are closely related. Western medicine is still no effective treatment. We use the original side Zhongjing Powder Dangguishaoyao Xiaoxianxiong soup made Treated PLGC119 Xiaoguishao patients treated with Weifuchun controlled study of 117 cases, are as follows. 1 data and case selection methods 1.1 Age> 18 years, with clinical symptoms consistent with diagnostic criteria for chronic atrophic gastritis (see ) and at 1 month confirmed by endoscopy and pathology with moderate or severe gastric epithelial dysplasia and (or) incomplete colonic type metaplasia. Where a diagnosis of suspected malignant pathology or combined heart, brain, liver, kidney and hematopoietic system of primary and other serious diseases, mental patients were excluded cases. 1.2 General information 236 cases were all patients of Gastroenterology, Hospital of Hebei Province, 2004-06-2005-12. Randomly divided into 2 groups, the treatment group 119 patients, 77 males and 42 females; aged 29 to 76 years, mean 56.6 years; average duration of 17.2 years; 83 cases of atrophy with intestinal metaplasia, dysplasia, 56 cases combined. Control group, 117 cases, male 72 cases, 45 females; aged 27 to 77 years, mean 55.9 years; average duration of 16.7 years; 85 cases of atrophy with intestinal metaplasia, dysplasia, 53 cases combined. General information 2 comparison group of patients was no significant difference (P> 0.05), comparable. 1.3 1.3.1 therapy for the treatment group Xiaoguishao particles (drugs: Coptis 6g, Pinellia 12g,MBT schuhe preise, Trichosanthes 30g, angelica 12g, white peony 20g, Chuan Xiong 10g , Poria 20g, Bai Zhu 15g, Alisma 6g. by the hospital of Chinese medicine preparation room processing in Hebei Province as granules, each bag containing crude drug 9g), 1 bag each time, 3 times daily, before meals, taking 30min. 1.3.2 Weifuchun control group to film (Hangzhou Hu Qing Yu Tang production Zhunzi: Z33020146), 4 tablets each time, 3 times daily before meals, taking 30min. 1.3.3 2 treatment groups were 3 months for a course of treatment, a course of treatment after the statistical treatment. 1.4 Observation items before and after treatment with different TCM syndromes, major changes in symptoms and tongue; blood, urine, routine, and then the heart, liver and renal function. 1.5 efficacy criterion-referenced signs of significant improvement in symptom scores decreased ≥ 70%; effective: symptoms, signs have improved symptom scores decreased ≥ 30%; invalid: symptoms and signs were not improved, or even increase, reduction of symptom scores less than 30%. Syndrome score in the formula (nimodipine method) as follows: [(before treatment points - points after treatment) ÷ points before treatment] × 100%. 1.6 statistical method used to compare the rate of count data χ 2 test, applied statistical processing software package SAS.